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Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

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Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Basic information

	Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
	(R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER;(R)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER;(R)-(-)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE;(R)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE;(S)-4-CYANO-3-HYDROXYBUTANOATE ETHYL;ETHYL (3R)-4-CYANO-3-HYDROXY-BUTANOATE;ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE;ETHYL (R)-4-CYANO-3-HYDROXYBUTANOATE
	141942-85-0
	C7H11NO3
	157.17
	430-220-6
	Atorvastatin intermediates;chiral;Alcohols, Hydroxy Esters and Derivatives;Chiral Compounds;INTERMEDIATESOFATORVASTATIN;API intermediates;Pharmaceutical Intermediates;141942-85-0
	141942-85-0.mol

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Chemical Properties

	-5 º (neat)
	270 degree (lit.)
	1.114 g/mL at 25 degree (lit.)
	n20/D 1.448(lit.)
	>230 degree F
	2-8 degree

	13.03±0.20(Predicted)

	1.114

	[ ]25/D 5 degree , neat
	5328715
	LOQFROBMBSKWQY-ZCFIWIBFSA-N
	141942-85-0(CAS DataBase Reference)

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Usage And Synthesis


	analgesic, antipyretic, and anti-inflammatory
	(3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester is used in a biocatalytic process for the synthesis of an atorvastatin intermediate and degredation products/impurities.
	Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a new class of lipid-lowering drugs, and they have a market share of more than 10 billion US dollars in the current pharmaceutical field. They can selectively inhibit the rate-limiting enzyme HMG-CoA reductase in cholesterol synthesis in the liver, reduce liver lipoprotein production, and increase the expression of low-density lipoprotein (LDL) cholesterol receptors, thereby reducing plasma cholesterol levels. They can also significantly reduce very low-density lipoprotein (VLDL) and triglycerides, and increase anti-atherosclerotic high-density protein (HDL), preventing atherosclerosis and coronary heart disease. Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is an important intermediate for the synthesis of HMG-CoA reductase inhibitors. If it is used as a raw material, synthetic atorvastatin is mainly used for the treatment of hypercholesterolemia and mixed hyperlipidemia, coronary heart disease and stroke.

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Preparation Products And Raw materials

	Butanoic acid, 4-cyano-3-hydroxy-, (3R)--->Ethyl 4-bromo-3-hydroxybutyrate-->Sodium cyanide-->Ethanol-->Ethyl 4-chloroacetoacetate
	(3R,5R)-6-Cyano-3,5-dihydroxy-hexanoic Acid tert-Butyl Ester

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